Library · Physiology

How the nephron works

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The nephron, which is one of the kidney's many filtering units, does its job in two steps, and to understand the order is to understand the whole thing. First the glomerulus, the filter, strains the blood. Then the tubule, the tube that follows, sorts through what was strained and returns to the blood whatever the body still needs, while letting the waste go.

The filter works by size. Its walls are so thin that they let small molecules, waste and fluid, almost all of it water, pass into the tubule; the big stuff, such as proteins and blood cells, does not fit and stays inside the blood vessel. Then, as the fluid runs along the tubule, almost all the water is recovered along with minerals and nutrients. What is left at the end, fluid and waste, is urine. It is like straining a whole pot at once and then fishing out by hand what was actually worth keeping: filtering is the fast part, picking is the fine work.

In brief

Nephrons work in two steps: the glomerulus filters the blood, and the tubule returns what the body needs and sends the waste out.

Filtering is the fast part; picking back out what was still useful is the fine work.

The thin walls of the glomerulus let fluid, waste and small molecules pass into the tubule; large ones, such as proteins and blood cells, do not get through.

Along the tubule almost all the water is reabsorbed, and the fluid and waste left behind become urine.

Sources (1)
  1. National Institute of Diabetes and Digestive and Kidney DiseasesYour Kidneys & How They Work

This page explains the topic in general terms; it does not tell anyone what treatment to follow.

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