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Hyperkalemia

Make it clearer

Hyperkalemia, spelled hyperkalaemia in British English, means having a potassium level, measured in serum or plasma, above the normal range. Potassium lives mostly inside the cells, not outside them.

What keeps it there is the sodium-potassium ATPase pump. It works much like a pump that lifts water to a rooftop tank, except that what it holds in place is potassium inside the cell. Blood potassium rises in one of three ways: more of it enters the body, it moves out of the cells, or the kidneys excrete less of it.

A mild rise often goes unnoticed. A severe one can trigger arrhythmias, disturbances of the heart rhythm that can be life-threatening, as well as muscle weakness or paralysis. And here is the key point: how fast the potassium level changes matters more than the number itself.

In brief

Hyperkalemia is a serum or plasma potassium concentration above the upper limit of normal.

Potassium is mostly intracellular, kept there by the sodium-potassium ATPase pump; serum levels rise with increased intake, a shift out of cells or reduced renal excretion.

Like a water pump, it keeps potassium inside the cell.

A mild rise often causes no symptoms; a severe one can trigger life-threatening cardiac arrhythmias, muscle weakness or paralysis. Symptoms can depend more on how quickly potassium levels rise than on how high they are.

Sources (1)
  1. National Center for Biotechnology Information, StatPearls PublishingHyperkalemia, StatPearlsPublished

This page explains the topic in general terms; it does not tell anyone what treatment to follow.

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