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Myotonic dystrophy
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Myotonic dystrophy combines progressive muscle weakness with myotonia. Myotonia means that a muscle contracts but takes longer to relax. Picture a fist that can close around an object but does not open immediately after letting go.
The problem begins with repeated segments of DNA. These repeats produce messenger RNA that is too long, collects inside cells, and interferes with several proteins. That is why myotonic dystrophy can affect muscles as well as other tissues.
In brief
Myotonic dystrophy is an inherited disease in the muscular dystrophy group. It causes progressive muscle wasting and weakness, along with a defining feature called myotonia: a prolonged contraction that makes certain muscles slow to relax after use.
The muscle contracts, then takes longer to release.
In type 1 and type 2 myotonic dystrophy, repeated DNA segments produce abnormally long messenger RNA molecules that collect inside cells and disrupt the production of several proteins. The resulting effects impair muscle function and can also involve other tissues.
Sources (1)
- MedlinePlus Genetics, U.S. National Library of MedicineMyotonic dystrophy
This page explains the topic in general terms; it does not tell anyone what treatment to follow.
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