Library · Histology

Peripheral Nerve Histology

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Peripheral nerve histology reveals a bundled organization. Picture many fine wires grouped into fascicles. Perineurium surrounds each fascicle, and the epineurium gathers them within an outer covering.

Inside the endoneurium are axons, myelin sheaths, Schwann cells, blood vessels, and interstitial collagen. The three key connective tissue layers, moving outward from the individual nerve fiber, are the endoneurium, perineurium, and epineurium.

In brief

Under the microscope, a peripheral nerve is organized into endoneurial fascicles surrounded by perineurium and gathered within the epineurium.

Picture many fine wires grouped into fascicles, with several fascicles gathered together inside one outer covering.

Within the endoneurium are axons, myelin sheaths, Schwann cells, blood vessels, and interstitial collagen. The three connective tissue coverings are the endoneurium, perineurium, and epineurium.

Sources (1)
  1. PubMed, U.S. National Library of MedicineMicrodissection of peripheral nerve: collagen and lipid distribution with morphological correlationPublished

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