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Ribosome

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The ribosome is the organelle that makes proteins, the molecules the cell uses to build almost everything it needs. An organelle is a part with a job of its own inside the cell, like the mitochondrion and the nucleus. Some ribosomes float loose in the cytoplasm, the gel-like interior of the cell, and others are attached to the rough endoplasmic reticulum, which is called rough precisely because it has them on its surface.

It is not a single piece. The ribosome is built by joining two subunits, one small and one large, like two halves of a shell closing together. And it is not made of protein alone: it is made of RNA and protein together.

The most curious part is which of them does the chemical work. Joining two amino acids, the building blocks of proteins, requires forming a peptide bond, and that reaction is sped up by ribosomal RNA, not by the ribosome's proteins, which are busy instead assembling the subunits.

Bacteria have a different ribosome from ours, and that difference has consequences: there are antibiotics that bind selectively to the bacterial ribosome.

In brief

The ribosome is the organelle that makes the cell's proteins; some float free in the cytoplasm and others are attached to the rough endoplasmic reticulum.

It assembles from two subunits, 40S and 60S in eukaryotic cells, which together form an 80S particle made of RNA and protein.

Ribosomal RNA, not the proteins, catalyzes the peptide bond; the proteins mostly assemble the subunits.

The bacterial ribosome is different, which is why certain antibiotics bind to it selectively.

Sources (2)
  1. National Center for Biotechnology Information, StatPearls PublishingHistology, Cell, StatPearlsPublished
  2. National Center for Biotechnology Information, StatPearls PublishingBiochemistry, Protein Synthesis, StatPearlsPublished

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