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Thyroid histology

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The thyroid is built from many follicles. Each follicle resembles a tiny hollow sphere: a single layer of follicular cells forms the wall, and the center holds colloid, a material rich in thyroglobulin.

At the boundary between the cells and colloid, components of the hormones T3 and T4 are made and stored. Capillaries and parafollicular cells lie between the spheres. As an endocrine gland, the thyroid releases hormones into the blood rather than through a duct to the outside.

In brief

Thyroid tissue is organized into follicles, rounded units lined by a single layer of follicular cells. Each follicle surrounds a central cavity filled with colloid, a material rich in the protein thyroglobulin.

Follicular cells produce thyroglobulin and work at the boundary with the colloid to make and store precursors of T3 and T4. Stroma, capillaries, and parafollicular cells lie between the follicles. The thyroid has no ducts that release hormones outside the body.

Sources (1)
  1. National Center for Biotechnology InformationHistology, Thyroid Gland

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